Wednesday, October 3, 2012

PM Note: A Video Tease, Debate Prep at Hoover Dam or Salsa Bar?, The Sound of Roberts and Kennedy

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Tuesday, October 2, 2012

ArQule stock plunges as lung cancer study shelved

NEW YORK (AP) ? ArQule Inc. stock lost more than half its value in Tuesday trading after the company said it stopped a clinical trial of its cancer drug tivantinib because the therapy was not improving survival in lung cancer patients.

ArQule and its partner Daiichi Sankyo of Japan said they stopped a late-stage study of tivantinib as a treatment for non-small cell lung cancer. The companies said patients who were being treated with tivantinib and Tarceva, another cancer drug, were not living longer than patients treated with Tarceva and a placebo. The trial was designed to compare how long patients lived after treatment with the two drug regimens.

The trial was stopped after a review by a committee of independent monitors. The committee said the study would not show that tivantinib patients were living longer.

Shares of ArQule lost $2.73, or 54.7 percent, to $2.26 in late morning trading. Earlier the stock dropped to $1.98, its lowest price in nearly four years.

Tivantinib is ArQule's most advanced drug, and Tuesday's failure was its second recent setback. In late August, the company's Japanese partner Kyowa Hakko Kirin Co. temporarily suspended enrollment of patients in a separate trial of tivantinib because some patients are believed to have contracted interstitial lung disease, a condition that causes scarring of the lung tissue and impair a patient's ability to breathe.

ArQule stock traded as high as $6.80 in mid-August, before that news.

The Woburn, Mass., company said Tuesday that tivantinib and Tarceva were more effective at stopping the progression of lung cancer than Tarceva alone: patients treated with the two-drug regimen had longer progression-free survival, which means they lived longer before death or the resumption of disease progression, whichever came first. The companies enrolled about 1,000 patients in the trial.

Daiichi Sankyo and ArQule are working together to develop tivantinib in the U.S., Europe, and other regions. Kyowa Hakko Kirin has the right to develop and market the drug in Japan, China, South Korea, and Taiwan.

Tarceva is a pill marketed by Roche of Switzerland. It is approved as a maintenance treatment for non-small cell lung cancer and a secondary treatment for pancreatic cancer.

Source: http://news.yahoo.com/arqule-stock-plunges-lung-cancer-study-shelved-144231165--finance.html

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BBC in talks to build Playlister, a streaming music service for its own music archive

BBC in talks to build Playlister, a streaming music service for its own music archive

The BBC is home to a massive archive of highly desirable music that, sadly, due to licensing reasons, remains gathering dust in is enormous vaults. The Telegraph is reporting that the corporation's music head, Tim Davie, is trying to put some or all of that material online for users to enjoy without additional charges. He's said to be in talks with Spotify, Deezer and Apple to help build a service called Playlister, using the trio's bulk-deals with the record labels to get around the long-winded wrangling that would otherwise be required. If successful, it'll launch in 2013 free to license-fee paying Brits in a similar fashion to the wildly successful iPlayer -- although we'd pay a little extra if Fearne Cotton was excluded from the catalog.

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BBC in talks to build Playlister, a streaming music service for its own music archive originally appeared on Engadget on Tue, 02 Oct 2012 15:41:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/10/02/bbc-playlister-rumor/

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Zinc deficiency mechanism linked to aging, multiple diseases

ScienceDaily (Oct. 1, 2012) ? A new study has outlined for the first time a biological mechanism by which zinc deficiency can develop with age, leading to a decline of the immune system and increased inflammation associated with many health problems, including cancer, heart disease, autoimmune disease and diabetes.

The research was done by scientists in the Linus Pauling Institute at Oregon State University and the OSU College of Public Health and Human Sciences. It suggests that it's especially important for elderly people to get adequate dietary intake of zinc, since they may need more of it at this life stage when their ability to absorb it is declining.

About 40 percent of elderly Americans and as many as two billion people around the world have diets that are deficient in this important, but often underappreciated micronutrient, experts say.

The study was published in the Journal of Nutritional Biochemistry, based on findings with laboratory animals. It found that zinc transporters were significantly dysregulated in old animals. They showed signs of zinc deficiency and had an enhanced inflammatory response even though their diet supposedly contained adequate amounts of zinc.

When the animals were given about 10 times their dietary requirement for zinc, the biomarkers of inflammation were restored to those of young animals.

"The elderly are the fastest growing population in the U.S. and are highly vulnerable to zinc deficiency," said Emily Ho, an LPI principal investigator. "They don't consume enough of this nutrient and don't absorb it very well."

"We've previously shown in both animal and human studies that zinc deficiency can cause DNA damage, and this new work shows how it can help lead to systemic inflammation," Ho said.

"Some inflammation is normal, a part of immune defense, wound healing and other functions," she said. "But in excess, it's been associated with almost every degenerative disease you can think of, including cancer and heart disease. It appears to be a significant factor in the diseases that most people die from."

As a result of this and what is now know about zinc absorption in the elderly, Ho said that she would recommend all senior citizens take a dietary supplement that includes the full RDA for zinc, which is 11 milligrams a day for men and 8 milligrams for women. Zinc can be obtained in the diet from seafood and meats, but it's more difficult to absorb from grains and vegetables -- a particular concern for vegetarians.

"We found that the mechanisms to transport zinc are disrupted by age-related epigenetic changes," said Carmen Wong, an OSU research associate and co-author of this study. "This can cause an increase in DNA methylation and histone modifications that are related to disease processes, especially cancer. Immune system cells are also particularly vulnerable to zinc deficiency."

Research at OSU and elsewhere has shown that zinc is essential to protect against oxidative stress and help repair DNA damage. In zinc deficiency, the risk of which has been shown to increase with age, the body's ability to repair genetic damage may be decreasing even as the amount of damage is going up.

Medical tests to determine zinc deficiency are rarely done, scientists say, and are not particularly accurate even if they are done. The best approach is to assure adequate intake of the nutrient through diet or supplements, they said, especially in the elderly.

Even though elderly people have less success in absorbing zinc, the official RDA for them is the same as in younger adults. That issue should be examined more closely, Ho said.

Levels of zinc intake above 40 milligrams per day should be avoided, researchers said, because at very high levels they can interfere with absorption of other necessary nutrients, including iron and copper.

These studies were supported by the National Institutes of Health and other agencies.

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Story Source:

The above story is reprinted from materials provided by Oregon State University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Juan P. Liuzzi, Carmen P. Wong, Emily Ho, Ashley Tracey. Regulation of hepatic suppressor of cytokine signaling 3 by zinc. The Journal of Nutritional Biochemistry, 2012; DOI: 10.1016/j.jnutbio.2012.07.011

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/uYxd7jdw73g/121001141003.htm

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Monday, October 1, 2012

105-yarder lifts Vikes over Lions

By LARRY LAGE

AP Sports Writer

Associated Press Sports

updated 5:49 p.m. ET Sept. 30, 2012

DETROIT (AP) - The Minnesota Vikings must have been salivating when they watched how the Detroit Lions covered kicks.

Or, more accurately, didn't cover them.

Percy Harvin returned the opening kickoff 105 yards, and Marcus Sherels ran back the first punt of the second half 77 yards for a score, boosting the Vikings to a 20-13 win Sunday - and sending the underachieving Lions into a dubious category all their own.

"It was slow-motion, especially today," Harvin said. "That hole opened up, and you probably could have walked through there. The blockers did a great job. They told me all week they were going to do everything they could to get me in the end zone. Special teams was huge today."

Vikings coach Leslie Frazier said he and his staff pointed out Detroit's deficiencies and predicted Harvin would score if everyone held their blocks.

"It was obvious," Frazier said.

When Sherels scored, Detroit became the first team since at least 1940 to give up a kickoff and a punt return for touchdowns in consecutive games, according to STATS LLC. The Lions allowed scores on a kickoff and punt in last week's 44-41 loss in overtime at Tennessee.

"We're good, but we're garbage right now and we're killing our team," kicker Jason Hanson said.

Lions coach Jim Schwartz, though, shot down any chance of him firing special teams coordinator Danny Crossman.

"No, that's not a consideration," Schwartz said. "There's physical plays we have to make."

The surprising NFC North-leading Vikings (3-1) have already matched the number of wins of 2011, when they got off to an 0-4 start.

Second-year quarterback Christian Ponder said that is huge.

"That's a good mark of improvement," Ponder said.

The Lions, meanwhile, seem to be regressing quickly.

Detroit (1-3) goes into its bye wondering what has gone wrong with a team that began 5-0 last season and ended with 10 victories to snap the franchise's 11-game postseason drought. The Lions have lost three straight - surpassing their longest skid last year - to turn cheers into jeers at Ford Field.

"We didn't start off the way we wanted to," Schwartz said. "That's not to say we can't get it back. That's s our challenge right now to dig our way out of this."

Beginning with special teams.

Harvin fielded the first kick toward the back left of the end zone, cut across the field, sprinted up the sideline and into the other end zone 12 seconds into the game.

"We always talk about starting fast, and that's the fastest start you can get," Ponder said.

As soon as the Vikings got the ball in the second half, they went to work quickly as well.

Sherels took the punt in the middle of the field and made Kassim Osgood miss right away before wiggling through traffic and pulling away to put the Vikings ahead 20-6.

Ponder was 16 of 26 for 111 yards for Minnesota. Jerome Simpson had four receptions for a team-high 50 yards and drew a pair of penalties to help set up scores. Simpson missed the first three games serving a suspension for violating the league's substance abuse policy.

Adrian Peterson had 102 yards rushing on 21 carries - running for more than 100 yards for the first time since Oct. 23, 2011 - and added more proof his surgically repaired left knee is just fine.

"It just seems like that was the Adrian that we were hoping to see," Frazier said.

Minnesota's defense wouldn't let the Lions look good on the ground for the second straight week. Mikel Leshoure ran for just 26 yards on 13 carries after having 100 yards rushing and a TD in his debut last week.

Matthew Stafford was 30 of 51 for 319 yards without much help from Lions teammates - the ones that dropped passes and those that allowed him to get sacked five times after giving up just four sacks combined in the first three games.

"We got our butts kicked up front with sacks and we couldn't run the ball," Schwartz said. "Physically we have to be better."

Mentally, too.

Pettigrew dropped a potential TD pass one play after Calvin Johnson had the football jarred loose in the end zone, forcing Detroit to settle for a field goal and a 13-6 halftime deficit.

Just when the Lions looked as if they were going to break through offensively, safety Jamarca Sanford forced Leshoure to fumble and recovered at the Vikings 29 late in the third quarter.

Detroit drove to the Vikings 7 early in the fourth, but unblocked defensive end Everson Griffen sacked Stafford to end the threat.

The Lions got right back down in scoring territory and Stafford scored on a 1-yard lunge with 2:56 left.

Vikings punter Chris Kluwe pinned Detroit on its 2 with 1:42 remaining. Stafford was sacked on the last snap at his 33, a fitting end to a game dominated by Minnesota's defense and special teams, ending an 11-game losing streak to division opponents.

If Chicago can't beat Dallas on the road Monday night, the Vikings will be alone atop the NFC North going into Week 5.

"We want to embrace it," Frazier said. "It was one of our goals when the season began, to win the NFC North."

NOTES: Detroit DE Cliff Avril left the game in the fourth quarter with a back injury. ... Vikings WR Michael Jenkins had a rib injury during the game. ... Minnesota avoided its first four-game losing streak against the Lions since losing five in row 1961-63.

---

Online: http://pro32.ap.org/poll and http://twitter.com/AP-NFL

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Rethink NFC East expectations?

??PFT: Eli Manning's mistakes sink the Giants (2-2), while LeSean McCoy's brilliance continues to boost Philadelphia (3-1). If the Eagles really kick this thing into gear, they could be the one ruling the NFC East.

Eagles' late gamble pays off in win vs. Giants

Given a second chance, Lawrence Tynes couldn't make the Philadelphia Eagles pay for a tactical gamble that nearly backfired. Tynes missed two field-goal tries from 54 yards with 15 seconds left and Philadelphia held on for a 19-17 victory over the New York Giants on Sunday night.

Source: http://nbcsports.msnbc.com/id/49232332/ns/sports-nfl/

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Fish getting smaller as the oceans warm

ScienceDaily (Sep. 30, 2012) ? Changes in ocean and climate systems could lead to smaller fish, according to a new study led by fisheries scientists at the University of British Columbia.

The study, published September 30 in the journal Nature Climate Change, provides the first-ever global projection of the potential reduction in the maximum size of fish in a warmer and less-oxygenated ocean.

The researchers used computer modeling to study more than 600 species of fish from oceans around the world and found that the maximum body weight they can reach could decline by 14-20 per cent between years 2000 and 2050, with the tropics being one of the most impacted regions.

"We were surprised to see such a large decrease in fish size," says the study's lead author William Cheung, an assistant professor at the UBC Fisheries Centre. "Marine fish are generally known to respond to climate change through changing distribution and seasonality. But the unexpectedly big effect that climate change could have on body size suggests that we may be missing a big piece of the puzzle of understanding climate change effects in the ocean."

This is the first global-scale application of the idea that fish growth is limited by oxygen supply, which was pioneered more than 30 years ago by Daniel Pauly, principal investigator with UBC's Sea Around Us Project and the study's co-author.

"It's a constant challenge for fish to get enough oxygen from water to grow, and the situation gets worse as fish get bigger," explains Pauly. "A warmer and less-oxygenated ocean, as predicted under climate change, would make it more difficult for bigger fish to get enough oxygen, which means they will stop growing sooner."

This study highlights the need to curb greenhouse gas emissions and develop strategies to monitor and adapt to changes that we are already seeing, or we risk disruption of fisheries, food security and the way ocean ecosystems work.

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Story Source:

The above story is reprinted from materials provided by University of British Columbia, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. William W. L. Cheung, Jorge L. Sarmiento, John Dunne, Thomas L. Fr?licher, Vicky W. Y. Lam, M. L. Deng Palomares, Reg Watson, Daniel Pauly. Shrinking of fishes exacerbates impacts of global ocean changes on marine ecosystems. Nature Climate Change, 2012; DOI: 10.1038/nclimate1691

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/YAN_hoMP_8c/120930142058.htm

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This Shopping Season, Consider a Trip to Nearby London, Ontario

?

Looking for some different and unique gifts for the upcoming holiday season? Or, maybe you just need a brief getaway to recharge the batteries. If that?s the case, you?ll want to explore the unique shops of nearby London, Ontario. And as a bonus, you can also make plans to attend London?s original craft show ? the 34th annual London Arts & Crafts Fall Show & Sale, taking place the weekend of Oct. 19-21.

The show never fails to deliver unique arts and craft items, featuring everything from clothing, jewelry and art to candles, pottery, woodworking, home decor items and much more!

Hours at the 34th annual London Arts & Crafts Fall Show & Sale are 1 to 9 p.m. Friday, Oct. 19; 11 a.m. to 6 p.m. Saturday, Oct. 20; and 11 a.m. to 5 p.m. Sunday, Oct. 21. The event will take place in the Canada?Building on the Western Fairgrounds, and admission is just $6. For more information, please call (519) 679-1810, email?optholdings@bellnet.ca or visit www.londoncraftshows.com.

If you like what you see, be sure to return for the 2012 Christmas Craft Festival taking place Dec. 6-9 in the Progress Building on the Western Fairgrounds!

And, no shopping trip to London would be complete without a visit to Richmond Row, London?s most interesting and innovative shopping district with more than 200 businesses catering to your every need. Whether you?re looking for things to buy, something to do, outstanding accommodations or a great place to eat, you?re sure to find it along Richmond Row!

For helpful information on planning a quick getaway to London, please visit www.londontourism.ca.

?

Source: http://westseneca.wgrz.com/news/events/69616-shopping-season-consider-trip-nearby-london-ontario

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